Optimization of inflow waveform phase-difference for minimized total cavopulmonary power loss.
نویسندگان
چکیده
The Fontan operation is a palliative surgical procedure performed on children, born with congenital heart defects that have yielded only a single functioning ventricle. The total cavo-pulmonary connection (TCPC) is a common variant of the Fontan procedure, where the superior vena cava (SVC) and inferior vena cava (IVC) are routed directly into the pulmonary arteries (PA). Due to the limited pumping energy available, optimized hemodynamics, in turn, minimized power loss, inside the TCPC pathway is required for the best optimal surgical outcomes. To complement ongoing efforts to optimize the anatomical geometric design of the surgical Fontan templates, here, we focused on the characterization of power loss changes due to the temporal variations in between SVC and IVC flow waveforms. An experimentally validated pulsatile computational fluid dynamics solver is used to quantify the effect of phase-shift between SVC and IVC inflow waveforms and amplitudes on internal energy dissipation. The unsteady hemodynamics of two standard idealized TCPC geometries are presented, incorporating patient-specific real-time PC-MRI flow waveforms of "functional" Fontan patients. The effects of respiration and pulsatility on the internal energy dissipation of the TCPC pathway are analyzed. Optimization of phase-shift between caval flows is shown to lead to lower energy dissipation up to 30% in these idealized models. For physiological patient-specific caval waveforms, the power loss is reduced significantly (up to 11%) by the optimization of all three major harmonics at the same mean pathway flow (3 L/min). Thus, the hemodynamic efficiency of single ventricle circuits is influenced strongly by the caval flow waveform quality, which is regulated through respiratory dependent physiological pathways. The proposed patient-specific waveform optimization protocol may potentially inspire new therapeutic applications to aid postoperative hemodynamics and improve the well being of the Fontan patients.
منابع مشابه
Particle Swarm Optimization with Smart Inertia Factor for Combined Heat and Power Economic Dispatch
In this paper particle swarm optimization with smart inertia factor (PSO-SIF) algorithm is proposed to solve combined heat and power economic dispatch (CHPED) problem. The CHPED problem is one of the most important problems in power systems and is a challenging non-convex and non-linear optimization problem. The aim of solving CHPED problem is to determine optimal heat and power of generating u...
متن کاملA Hybrid Switching Technique for Single-Phase AC-Module PV System to Reduce Power Losses and Minimize THD
This paper proposes a hybrid switching technique for a domestic PV system with AC-module architecture. In this PV system, independent control of PV modules, which are directly connected to DC terminals of a single-phase cascaded multilevel inverter, makes module-level MPPT possible to extract maximum available solar energy, especially in partial shading conditions. As one of the main contributi...
متن کاملDiscretized Adjoint State Time and Frequency Domain Full Waveform Inversion: A Comparative Study
This study derives the discretized adjoint states full waveform inversion (FWI) in both time and frequency domains based on the Lagrange multiplier method. To achieve this, we applied adjoint state inversion on the discretized wave equation in both time domain and frequency domain. Besides, in this article, we introduce reliability tests to show that the inversion is performing as it should be ...
متن کاملComparative Harmonic Loss Measurement of Grain Oriented and Non-oriented Magnetic Sheets Using a High Precision Single Sheet Tester
Abstract: Local flux may be distorted in many regions of core, although total flux is usually sinusoidal. When attempting to predict the loss distribution in materials operating under localized distorted flux conditions, which occur in machines and transformer cores, it is essential that proper account of the waveform be taken. Moreover for development of new magnetic materials and generation ...
متن کاملA New Optimization Algorithm for Optimal Wind Turbine Location Problem in Constantine City Electric Distribution Network Based Active Power Loss Reduction
The wind turbine has grown out to be one of the most common Renewable Energy Sources (RES) around the world in recent years. This study was intended to position the Wind Turbine (WT) on a wind farm to achieve the highest performance possible in Electric Distribution Network (EDN). In this paper a new optimization algorithm namely Salp Swarm Algorithm (SSA) is applied to solve the problem of opt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of biomechanical engineering
دوره 132 3 شماره
صفحات -
تاریخ انتشار 2010